Biallelic, ubiquitous transcription from the distal germline Igκ locus promoter during B cell development

Allelic exclusion of Ig gene expression is necessary to limit the number of functional receptors to one per B cell. The mechanism underlying allelic exclusion is unknown. Because germline transcription of Ig and TCR loci is tightly correlated with rearrangement, we created two novel knock-in mice th...

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Detalhes bibliográficos
Main Authors: Amin, Rupesh H., Cado, Dragana, Nolla, Hector, Huang, Dan, Shinton, Susan A., Zhou, Yan, Hardy, Richard R., Schlissel, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626736/
https://ncbi.nlm.nih.gov/pubmed/19116268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808895106
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