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Chromosomal position of a V(H) gene segment determines its activation and inactivation as a substrate for V(D)J recombination
Complete IgHC gene rearrangement occurs only in B cells in a stage-specific and ordered manner. We used gene targeting to reposition a distal V(H) gene segment to a region just 5′ of the D(H) gene cluster and found its activation to be highly dependent on the chromosomal domain within which it resid...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2150984/ https://ncbi.nlm.nih.gov/pubmed/18056289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071787 |
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