BRCA1 Inhibition of Telomerase Activity in Cultured Cells

Telomerase, an enzyme that maintains telomere length, plays major roles in cellular immortalization and cancer progression. We found that an exogenous BRCA1 gene strongly inhibited telomerase enzymatic activity in human prostate and breast cancer cell lines and caused telomere shortening in cell lin...

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Detalhes bibliográficos
Main Authors: Xiong, Jingbo, Fan, Saijun, Meng, Qinghui, Schramm, Laura, Wang, Chenguang, Bouzahza, Boumedienne, Zhou, Jinnian, Zafonte, Brian, Goldberg, Itzhak D., Haddad, Bassem R., Pestell, Richard G., Rosen, Eliot M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262673/
https://ncbi.nlm.nih.gov/pubmed/14612409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.23.8668-8690.2003
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