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BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage
BRCA1, a tumor suppressor, participates in DNA damage signaling and repair. Previously, we showed that BRCA1 overexpression caused inhibition of telomerase activity and telomere shortening in breast and prostate cancer cells. We now report that BRCA1 knockdown causes increased telomerase reverse tra...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794724/ https://ncbi.nlm.nih.gov/pubmed/19797051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025825 |
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