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Activity of Metal-Responsive Transcription Factor 1 by Toxic Heavy Metals and H(2)O(2) In Vitro Is Modulated by Metallothionein

Metallothioneins are small, cysteine-rich proteins that avidly bind heavy metals such as zinc, copper, and cadmium to reduce their concentration to a physiological or nontoxic level. Metallothionein gene transcription is induced by several stimuli, notably heavy metal load and oxidative stress. Tran...

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Udgivet i:Mol Cell Biol
Principais autores: Zhang, Bo, Georgiev, Oleg, Hagmann, Michael, Günes, Çagatay, Cramer, Mirjam, Faller, Peter, Vasák, Milan, Schaffner, Walter
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262672/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14612393/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.23.8471-8485.2003
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