Activity of Metal-Responsive Transcription Factor 1 by Toxic Heavy Metals and H(2)O(2) In Vitro Is Modulated by Metallothionein

Metallothioneins are small, cysteine-rich proteins that avidly bind heavy metals such as zinc, copper, and cadmium to reduce their concentration to a physiological or nontoxic level. Metallothionein gene transcription is induced by several stimuli, notably heavy metal load and oxidative stress. Tran...

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Detalhes bibliográficos
Main Authors: Zhang, Bo, Georgiev, Oleg, Hagmann, Michael, Günes, Çagatay, Cramer, Mirjam, Faller, Peter, Vasák, Milan, Schaffner, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262672/
https://ncbi.nlm.nih.gov/pubmed/14612393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.23.8471-8485.2003
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