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Knockout of ‘metal-responsive transcription factor’ MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis

‘Metal-responsive transcription factor-1’ (MTF-1), a zinc finger protein, is conserved from mammals to insects. In the mouse, it activates metallothionein genes and other target genes in response to several cell stress conditions, notably heavy metal load. The knockout of MTF-1 in the mouse has an e...

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Dettagli Bibliografici
Autori principali: Egli, Dieter, Selvaraj, Anand, Yepiskoposyan, Hasmik, Zhang, Bo, Hafen, Ernst, Georgiev, Oleg, Schaffner, Walter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC140060/
https://ncbi.nlm.nih.gov/pubmed/12505988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg012
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