Knockout of ‘metal-responsive transcription factor’ MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis

‘Metal-responsive transcription factor-1’ (MTF-1), a zinc finger protein, is conserved from mammals to insects. In the mouse, it activates metallothionein genes and other target genes in response to several cell stress conditions, notably heavy metal load. The knockout of MTF-1 in the mouse has an e...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Egli, Dieter, Selvaraj, Anand, Yepiskoposyan, Hasmik, Zhang, Bo, Hafen, Ernst, Georgiev, Oleg, Schaffner, Walter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12505988/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg012
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