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Mucosal immunization with attenuated Salmonella Typhi expressing anthrax PA83 primes monkeys for accelerated serum antibody responses to parenteral PA83 vaccine

Salmonella enterica serovar Typhi vaccine strain CVD 908-htrA was genetically engineered for stable plasmid-based expression of protective antigen of anthrax toxin (PA83) fused with the export protein ClyA (ClyA-PA83). The priming potential of CVD 908-htrA expressing ClyA-PA83 was assessed in 12 rhe...

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Detalhes bibliográficos
Main Authors: Galen, James E., Chinchilla, Magaly, Pasetti, Marcela F., Wang, Jin Yuan, Zhao, Licheng, Arciniega-Martinez, Ivonne, Silverman, David J., Levine, Myron M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626152/
https://ncbi.nlm.nih.gov/pubmed/19099487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/596066
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