Adaptation of the Endogenous Salmonella enterica Serovar Typhi clyA-Encoded Hemolysin for Antigen Export Enhances the Immunogenicity of Anthrax Protective Antigen Domain 4 Expressed by the Attenuated Live-Vector Vaccine Strain CVD 908-htrA

Bacterial live-vector vaccines aim to deliver foreign antigens to the immune system and induce protective immune responses, and surface-expressed or secreted antigens are generally more immunogenic than cytoplasmic constructs. We hypothesize that an optimum expression system will use an endogenous e...

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Detalhes bibliográficos
Main Authors: Galen, James E., Zhao, Licheng, Chinchilla, Magaly, Wang, Jin Yuan, Pasetti, Marcela F., Green, Jeffrey, Levine, Myron M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529119/
https://ncbi.nlm.nih.gov/pubmed/15557633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.12.7096-7106.2004
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