Expression and Immunogenicity of a Mutant Diphtheria Toxin Molecule, CRM(197), and Its Fragments in Salmonella typhi Vaccine Strain CVD 908-htrA

Mutant diphtheria toxin molecule CRM(197) and fragments thereof were expressed in attenuated Salmonella typhi CVD 908-htrA, and the constructs were tested for their ability to induce serum antitoxin. Initially, expressed proteins were insoluble, and the constructs failed to induce neutralizing antit...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Orr, Nadav, Galen, James E., Levine, Myron M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Microbial Immunity and Vaccines
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96741/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10417208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.8.4290-4294.1999
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