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Expression and Immunogenicity of a Mutant Diphtheria Toxin Molecule, CRM(197), and Its Fragments in Salmonella typhi Vaccine Strain CVD 908-htrA
Mutant diphtheria toxin molecule CRM(197) and fragments thereof were expressed in attenuated Salmonella typhi CVD 908-htrA, and the constructs were tested for their ability to induce serum antitoxin. Initially, expressed proteins were insoluble, and the constructs failed to induce neutralizing antit...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC96741/ https://ncbi.nlm.nih.gov/pubmed/10417208 |
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