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Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
Results of transgenetic studies argue that the scrapie isoform of the prion protein (PrP(Sc)) interacts with the substrate cellular PrP (PrP(C)) during conversion into nascent PrP(Sc). While PrP(Sc) appears to accumulate primarily in lysosomes, caveolae-like domains (CLDs) have been suggested to be...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences of the USA
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC26242/ https://ncbi.nlm.nih.gov/pubmed/8962161 |
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