Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

Results of transgenetic studies argue that the scrapie isoform of the prion protein (PrP(Sc)) interacts with the substrate cellular PrP (PrP(C)) during conversion into nascent PrP(Sc). While PrP(Sc) appears to accumulate primarily in lysosomes, caveolae-like domains (CLDs) have been suggested to be...

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Autores principales: Vey, Martin, Pilkuhn, Susanne, Wille, Holger, Nixon, Randal, DeArmond, Stephen J., Smart, Eric J., Anderson, Richard G. W., Taraboulos, Albert, Prusiner, Stanley B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1996
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC26242/
https://ncbi.nlm.nih.gov/pubmed/8962161
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