Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

Results of transgenetic studies argue that the scrapie isoform of the prion protein (PrP(Sc)) interacts with the substrate cellular PrP (PrP(C)) during conversion into nascent PrP(Sc). While PrP(Sc) appears to accumulate primarily in lysosomes, caveolae-like domains (CLDs) have been suggested to be...

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Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Vey, Martin, Pilkuhn, Susanne, Wille, Holger, Nixon, Randal, DeArmond, Stephen J., Smart, Eric J., Anderson, Richard G. W., Taraboulos, Albert, Prusiner, Stanley B.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962161/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14945
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