Genetic Variation on Chromosome 6 Influences F Cell Levels in Healthy Individuals of African Descent and HbF Levels in Sickle Cell Patients

Fetal haemoglobin (HbF) is a major ameliorating factor in sickle cell disease. We investigated if a quantitative trait locus on chromosome 6q23 was significantly associated with HbF and F cell levels in individuals of African descent. Single nucleotide polymorphisms (SNPs) in a 24-kb intergenic regi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Creary, Lisa E., Ulug, Pinar, Menzel, Stephan, McKenzie, Colin A., Hanchard, Neil A., Taylor, Veronica, Farrall, Martin, Forrester, Terrence E., Thein, Swee Lay
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2009
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2621086/
https://ncbi.nlm.nih.gov/pubmed/19148297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004218
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