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Spinal Dynorphin and Bradykinin Receptors Maintain Inflammatory Hyperalgesia

An upregulation of the endogenous opioid, dynorphin A, in the spinal cord is seen in multiple experimental models of chronic pain. Recent findings implicate a direct excitatory action of dynorphin A at bradykinin receptors to promote hyperalgesia in nerve injured rats, and its upregulation may promo...

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Detalhes bibliográficos
Main Authors: Luo, Miaw-Chyi, Chen, Qingmin, Ossipov, Michael H., Rankin, David R., Porreca, Frank, Lai, Josephine
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615572/
https://ncbi.nlm.nih.gov/pubmed/18976961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2008.06.005
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