Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa
Factor VIIa (VIIa), the serine protease that initiates the coagulation pathways, is catalytically activated upon binding to its cell surface receptor and cofactor tissue factor (TF). This study provides a comprehensive analysis of the functional surface of VIIa by alanine scanning mutagenesis of 112...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1996
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26140/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962059/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14379 |
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