Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa

Factor VIIa (VIIa), the serine protease that initiates the coagulation pathways, is catalytically activated upon binding to its cell surface receptor and cofactor tissue factor (TF). This study provides a comprehensive analysis of the functional surface of VIIa by alanine scanning mutagenesis of 112...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Dickinson, Craig D., Kelly, Curtis R., Ruf, Wolfram
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1996
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26140/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962059/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14379
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