Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa

Factor VIIa (VIIa), the serine protease that initiates the coagulation pathways, is catalytically activated upon binding to its cell surface receptor and cofactor tissue factor (TF). This study provides a comprehensive analysis of the functional surface of VIIa by alanine scanning mutagenesis of 112...

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Bibliographic Details
Main Authors: Dickinson, Craig D., Kelly, Curtis R., Ruf, Wolfram
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1996
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC26140/
https://ncbi.nlm.nih.gov/pubmed/8962059
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