Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa

Factor VIIa (VIIa), the serine protease that initiates the coagulation pathways, is catalytically activated upon binding to its cell surface receptor and cofactor tissue factor (TF). This study provides a comprehensive analysis of the functional surface of VIIa by alanine scanning mutagenesis of 112...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Dickinson, Craig D., Kelly, Curtis R., Ruf, Wolfram
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26140/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962059/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14379
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