The Stability and Transactivation Potential of the Mammalian MafA Transcription Factor Are Regulated by Serineí 65 Phosphorylation

The level of the MafA transcription factor is regulated by a variety of effectors of β cell function, including glucose, fatty acids, and insulin. Here, we show that phosphorylation at Ser(65) of mammalian MafA influences both protein stability and transactivation potential. Replacement of Ser(65) w...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Guo, Shuangli, Burnette, Ryan, Zhao, Li, Vanderford, Nathan L., Poitout, Vincent, Hagman, Derek K., Henderson, Eva, Özcan, Sabire, Wadzinski, Brian E., Stein, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613637/
https://ncbi.nlm.nih.gov/pubmed/19004825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806314200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados