The Stability and Transactivation Potential of the Mammalian MafA Transcription Factor Are Regulated by Serineí 65 Phosphorylation

The level of the MafA transcription factor is regulated by a variety of effectors of β cell function, including glucose, fatty acids, and insulin. Here, we show that phosphorylation at Ser(65) of mammalian MafA influences both protein stability and transactivation potential. Replacement of Ser(65) w...

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Autores principales: Guo, Shuangli, Burnette, Ryan, Zhao, Li, Vanderford, Nathan L., Poitout, Vincent, Hagman, Derek K., Henderson, Eva, Özcan, Sabire, Wadzinski, Brian E., Stein, Roland
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613637/
https://ncbi.nlm.nih.gov/pubmed/19004825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806314200
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