The Stability and Transactivation Potential of the Mammalian MafA Transcription Factor Are Regulated by Serineí 65 Phosphorylation

The level of the MafA transcription factor is regulated by a variety of effectors of β cell function, including glucose, fatty acids, and insulin. Here, we show that phosphorylation at Ser(65) of mammalian MafA influences both protein stability and transactivation potential. Replacement of Ser(65) w...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Guo, Shuangli, Burnette, Ryan, Zhao, Li, Vanderford, Nathan L., Poitout, Vincent, Hagman, Derek K., Henderson, Eva, Özcan, Sabire, Wadzinski, Brian E., Stein, Roland
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613637/
https://ncbi.nlm.nih.gov/pubmed/19004825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806314200
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars