The Stability and Transactivation Potential of the Mammalian MafA Transcription Factor Are Regulated by Serineí 65 Phosphorylation

The level of the MafA transcription factor is regulated by a variety of effectors of β cell function, including glucose, fatty acids, and insulin. Here, we show that phosphorylation at Ser(65) of mammalian MafA influences both protein stability and transactivation potential. Replacement of Ser(65) w...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Guo, Shuangli, Burnette, Ryan, Zhao, Li, Vanderford, Nathan L., Poitout, Vincent, Hagman, Derek K., Henderson, Eva, Özcan, Sabire, Wadzinski, Brian E., Stein, Roland
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Protein Synthesis, Post-Translational Modification, and Degradation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613637/
https://ncbi.nlm.nih.gov/pubmed/19004825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806314200
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