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Noonan Syndrome/Leukemia-associated Gain-of-function Mutations in SHP-2 Phosphatase (PTPN11) Enhance Cell Migration and Angiogenesis

Mutations in SHP-2 phosphatase (PTPN11) that cause hyperactivation of its catalytic activity have been identified in Noonan syndrome and various childhood leukemias. Recent studies suggest that the gain-of-function (GOF) mutations of SHP-2 play a causal role in the pathogenesis of these diseases. Ho...

詳細記述

保存先:
書誌詳細
主要な著者: Wang, Siying, Yu, Wen-Mei, Zhang, Wanming, McCrae, Keith R., Neel, Benjamin G., Qu, Cheng-Kui
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613626/
https://ncbi.nlm.nih.gov/pubmed/19008228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804129200
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