Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)

BACKGROUND: The ubiquitous non-receptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) plays a key role in RAS/ERK signaling downstream of most, if not all growth factors, cytokines and integrins, although its major substrates remain controversial. Mutations in PTPN11 lead to several distinct...

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Detalhes bibliográficos
Main Authors: Qiu, Wei, Wang, Xiaonan, Romanov, Vladimir, Hutchinson, Ashley, Lin, Andrés, Ruzanov, Maxim, Battaile, Kevin P, Pai, Emil F, Neel, Benjamin G, Chirgadze, Nickolay Y
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007598/
https://ncbi.nlm.nih.gov/pubmed/24628801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-14-10
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