A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

Germline and somatic gain-of-function mutations in tyrosine phosphatase PTPN11 (SHP-2) are associated with juvenile myelomonocytic leukemia (JMML), a myeloproliferative disease (MPD) of early childhood. The mechanism by which PTPN11 mutations induce this disease is not fully understood. Signaling pa...

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Detalhes bibliográficos
Main Authors: Xu, Dan, Wang, Siying, Yu, Wen-Mei, Chan, Gordon, Araki, Toshiyuki, Bunting, Kevin D., Neel, Benjamin G., Qu, Cheng-Kui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981480/
https://ncbi.nlm.nih.gov/pubmed/20651068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-265652
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