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Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5

The peptide toxin ProTxII, recently isolated from the venom of the tarantula spider Thrixopelma pruriens, modifies gating in voltage-gated Na(+) and Ca(2+) channels. ProTxII is distinct from other known Na(+) channel gating modifier toxins in that it affects activation, but not inactivation. It shif...

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Main Authors: Edgerton, Gabrielle B., Blumenthal, Kenneth M., Hanck, Dorothy A.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613288/
https://ncbi.nlm.nih.gov/pubmed/18657562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2008.06.023
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