Non-obese diabetic–recombination activating gene-1 (NOD–Rag 1 (null)) interleukin (IL)-2 receptor common gamma chain (IL 2 rγ(null)) null mice: a radioresistant model for human lymphohaematopoietic engraftment

Immunodeficient hosts engrafted with human lymphohaematopoietic cells hold great promise as a preclinical bridge for understanding human haematopoiesis and immunity. We now describe a new immunodeficient radioresistant non-obese diabetic mice (NOD) stock based on targeted mutations in the recombinat...

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Dettagli Bibliografici
Autori principali: Pearson, T, Shultz, L D, Miller, D, King, M, Laning, J, Fodor, W, Cuthbert, A, Burzenski, L, Gott, B, Lyons, B, Foreman, O, Rossini, A A, Greiner, D L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2008
Soggetti:
Animal Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612717/
https://ncbi.nlm.nih.gov/pubmed/18785974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03753.x
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