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Death Receptor-Induced Activation of the Chk2- and Histone H2AX-Associated DNA Damage Response Pathways

TRAIL is an endogenous death receptor ligand also used therapeutically because of its selective proapoptotic activity in cancer cells. In the present study, we examined chromatin alterations induced by TRAIL and show that TRAIL induces a rapid activation of DNA damage response (DDR) pathways with hi...

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Bibliografiske detaljer
Main Authors: Solier, Stéphanie, Sordet, Olivier, Kohn, Kurt W., Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612481/
https://ncbi.nlm.nih.gov/pubmed/18955500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00581-08
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