Death Receptor-Induced Activation of the Chk2- and Histone H2AX-Associated DNA Damage Response Pathways

TRAIL is an endogenous death receptor ligand also used therapeutically because of its selective proapoptotic activity in cancer cells. In the present study, we examined chromatin alterations induced by TRAIL and show that TRAIL induces a rapid activation of DNA damage response (DDR) pathways with hi...

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Detaylı Bibliyografya
Asıl Yazarlar: Solier, Stéphanie, Sordet, Olivier, Kohn, Kurt W., Pommier, Yves
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612481/
https://ncbi.nlm.nih.gov/pubmed/18955500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00581-08
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