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Death Receptor-Induced Activation of the Chk2- and Histone H2AX-Associated DNA Damage Response Pathways
TRAIL is an endogenous death receptor ligand also used therapeutically because of its selective proapoptotic activity in cancer cells. In the present study, we examined chromatin alterations induced by TRAIL and show that TRAIL induces a rapid activation of DNA damage response (DDR) pathways with hi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2612481/ https://ncbi.nlm.nih.gov/pubmed/18955500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00581-08 |
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