Two Distinct Translesion Synthesis Pathways across a Lipid Peroxidation-derived DNA Adduct in Mammalian Cells

Translesion DNA synthesis (TLS) of damaged DNA templates is catalyzed by specialized DNA polymerases. To probe the cellular TLS mechanism, a host-vector system consisting of mouse fibroblasts and a replicating plasmid bearing a single DNA adduct was developed. This system was used to explore the TLS...

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Hlavní autoři: Yang, In-Young, Hashimoto, Keiji, de Wind, Niels, Blair, Ian A., Moriya, Masaaki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610493/
https://ncbi.nlm.nih.gov/pubmed/18981176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806414200
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