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c-FLIP Knockdown Induces Ligand-independent DR5-, FADD-, Caspase-8-, and Caspase-9-dependent Apoptosis in Breast Cancer Cells
Cellular-FLICE inhibitory protein (c-FLIP) is an inhibitor of apoptosis downstream of the death receptors Fas, DR4, and DR5, and is expressed as long (c-FLIP(L)) and short (c-FLIP(S)) splice forms. We found that the knockdown of c-FLIP using small interfering RNA (siRNA) triggered ligand-independent...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610355/ https://ncbi.nlm.nih.gov/pubmed/18840411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.09.007 |
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