Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1

The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II (pol II) by suppressing transient pausing of the pol II at many sites along the DNA. Elongin is composed of a transcriptionally active A subunit and two small regulatory B and C subunits, which can form an isola...

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Hlavní autoři: Yasukawa, Takashi, Kamura, Takumi, Kitajima, Shigetaka, Conaway, Ronald C, Conaway, Joan W, Aso, Teijiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2609743/
https://ncbi.nlm.nih.gov/pubmed/19037258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.249
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