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Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

The von Hippel-Lindau tumor suppressor protein (pVHL) negatively regulates hypoxia-inducible mRNAs such as the mRNA encoding vascular endothelial growth factor (VEGF). This activity has been linked to its ability to form multimeric complexes that contain elongin C, elongin B, and Cul2. To understand...

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Udgivet i:J Clin Invest
Principais autores: Ohh, Michael, Takagi, Yuichiro, Aso, Teijiro, Stebbins, Charles E., Pavletich, Nikola P., Zbar, Bert, Conaway, Ronald C., Conaway, Joan Weliky, Kaelin, William G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC481054/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10587522/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8161
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