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Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

SirT1 is an NAD-dependent histone deacetylase that regulates gene expression, differentiation, development, and organism life span. Here we investigate the function of SirT1 in human chondrocytes derived from osteoarthritic patients. Elevation of SirT1 protein levels or activity in these chondrocyte...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Dvir-Ginzberg, Mona, Gagarina, Viktoria, Lee, Eun-Jin, Hall, David J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605985/
https://ncbi.nlm.nih.gov/pubmed/18957417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803196200
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