Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

A library of drugs that are in clinical trials or use was screened for inhibitors of hypoxia-inducible factor 1 (HIF-1). Twenty drugs inhibited HIF-1-dependent gene transcription by >88% at a concentration of 0.4 μM. Eleven of these drugs were cardiac glycosides, including digoxin, ouabain, and p...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zhang, Huafeng, Qian, David Z., Tan, Yee Sun, Lee, KangAe, Gao, Ping, Ren, Yunzhao R., Rey, Sergio, Hammers, Hans, Chang, Daniel, Pili, Roberto, Dang, Chi V., Liu, Jun O., Semenza, Gregg L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604945/
https://ncbi.nlm.nih.gov/pubmed/19020076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809763105
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker