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G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth
Hypoxia-inducible factor-1 (HIF-1) plays crucial roles in tumor promotion by upregulating its target genes, which are involved in energy metabolism, angiogenesis, cell survival, invasion, metastasis, and drug resistance. The HIF-1α subunit, which is regulated by O(2)-dependent hydroxylation, ubiquit...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2839212/ https://ncbi.nlm.nih.gov/pubmed/19755960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.219 |
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