G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth

Hypoxia-inducible factor-1 (HIF-1) plays crucial roles in tumor promotion by upregulating its target genes, which are involved in energy metabolism, angiogenesis, cell survival, invasion, metastasis, and drug resistance. The HIF-1α subunit, which is regulated by O(2)-dependent hydroxylation, ubiquit...

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Main Authors: Guan, Yongli, Ramasamy Reddy, Kavitha, Zhu, Qiqing, Li, Yifei, Lee, KangAe, Weerasinghe, Priya, Prchal, Josef, Semenza, Gregg L, Jing, Naijie
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839212/
https://ncbi.nlm.nih.gov/pubmed/19755960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.219
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