G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth

Hypoxia-inducible factor-1 (HIF-1) plays crucial roles in tumor promotion by upregulating its target genes, which are involved in energy metabolism, angiogenesis, cell survival, invasion, metastasis, and drug resistance. The HIF-1α subunit, which is regulated by O(2)-dependent hydroxylation, ubiquit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Guan, Yongli, Ramasamy Reddy, Kavitha, Zhu, Qiqing, Li, Yifei, Lee, KangAe, Weerasinghe, Priya, Prchal, Josef, Semenza, Gregg L, Jing, Naijie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839212/
https://ncbi.nlm.nih.gov/pubmed/19755960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.219
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados