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Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
HIF-1 is a heterodimeric transcription factor that mediates adaptive responses to hypoxia and plays critical roles in cancer progression. Using a cell-based screening assay we have identified acriflavine as a drug that binds directly to HIF-1α and HIF-2α and inhibits HIF-1 dimerization and transcrip...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764905/ https://ncbi.nlm.nih.gov/pubmed/19805192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909353106 |
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