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Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
A library of drugs that are in clinical trials or use was screened for inhibitors of hypoxia-inducible factor 1 (HIF-1). Twenty drugs inhibited HIF-1-dependent gene transcription by >88% at a concentration of 0.4 μM. Eleven of these drugs were cardiac glycosides, including digoxin, ouabain, and p...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2604945/ https://ncbi.nlm.nih.gov/pubmed/19020076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809763105 |
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