Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

Digoxin and other cardiac glycosides inhibit hypoxia-inducible factor-1 (HIF-1) transcriptional activity in cultured cells and suppress tumor xenograft growth. We tested the hypothesis that digoxin reduces HIF-1 levels in ischemic tissue in vivo and suppresses neovascularization. Well-established mu...

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Bibliographic Details
Main Authors: Yoshida, Tsunehiko, Zhang, Huafeng, Iwase, Takeshi, Shen, Jikui, Semenza, Gregg L., Campochiaro, Peter A.
Format: Artigo
Language:Inglês
Published: The Federation of American Societies for Experimental Biology 2010
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874483/
https://ncbi.nlm.nih.gov/pubmed/20065104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-145664
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