HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease

Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease. Here, we shift our attention upstream from the genes that promote retinal neovascularization (NV) to the...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhang, Jing, Qin, Yaowu, Martinez, Mireya, Flores-Bellver, Miguel, Rodrigues, Murilo, Dinabandhu, Aumreetam, Cao, Xuan, Deshpande, Monika, Qin, Yu, Aparicio-Domingo, Silvia, Rui, Yuan, Tzeng, Stephany Y., Salman, Shaima, Yuan, Jin, Scott, Adrienne W., Green, Jordan J., Canto-Soler, M. Valeria, Semenza, Gregg L., Montaner, Silvia, Sodhi, Akrit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203455/
https://ncbi.nlm.nih.gov/pubmed/34128478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI139202
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