Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

Ischemia induces the production of angiogenic cytokines and the homing of bone-marrow-derived angiogenic cells (BMDACs), but these adaptive responses become impaired with aging because of reduced expression of hypoxia-inducible factor (HIF)-1α. In this study, we analyzed the effect of augmenting HIF...

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Detalhes bibliográficos
Main Authors: Rey, Sergio, Lee, KangAe, Wang, C. Joanne, Gupta, Kshitiz, Chen, Shaoping, McMillan, Alexandra, Bhise, Nupura, Levchenko, Andre, Semenza, Gregg L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787122/
https://ncbi.nlm.nih.gov/pubmed/19948968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911921106
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