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Biosynthesis of the Potent Antimalarial Compound FR900098

The antibiotics fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent anti-bacterial and anti-malarial compounds, but despite their efficacy, little is known regarding their bios...

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Hlavní autoři: Eliot, Andrew C., Griffin, Benjamin M., Thomas, Paul M., Johannes, Tyler W., Kelleher, Neil L., Zhao, Huimin, Metcalf, William W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603629/
https://ncbi.nlm.nih.gov/pubmed/18721747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.07.010
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