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Characterization of the Flavin Monooxygenase Involved in Biosynthesis of the Antimalarial FR-900098

The latter steps in this biosynthetic pathway for the antimalarial phosphonic acid FR-900098 include the installation of a hydroxamate onto 3-aminopropylphosphonate, which is catalyzed by the consecutive actions of an acetyltransferase and an amine hydroxylase. Here, we present the 1.6 Å resolution...

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Detalles Bibliográficos
Publicado en:Org Biomol Chem
Autores principales: Nguyen, Kim, DeSieno, Matthew A., Bae, Brian, Johannes, Tyler W., Cobb, Ryan E., Zhao, Huimin, Nair, Satish K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365201/
https://ncbi.nlm.nih.gov/pubmed/30681110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02840k
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