The Apolar Channel in Cerebratulus lacteus Hemoglobin Is the Route for O(2) Entry and Exit

The major pathway for O(2) binding to mammalian myoglobins (Mb) and hemoglobins (Hb) involves transient upward movement of the distal histidine (His-64(E7)), allowing ligand capture in the distal pocket. The mini-globin from Cerebratulus lacteus (CerHb) appears to have an alternative pathway between...

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Hauptverfasser: Salter, Mallory D., Nienhaus, Karin, Nienhaus, G. Ulrich, Dewilde, Sylvia, Moens, Luc, Pesce, Alessandra, Nardini, Marco, Bolognesi, Martino, Olson, John S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602902/
https://ncbi.nlm.nih.gov/pubmed/18840607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805727200
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