Exploring TAR–RNA aptamer loop–loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance

In HIV-1, trans-activation of transcription of the viral genome is regulated by an imperfect hairpin, the trans-activating responsive (TAR) RNA element, located at the 5′ untranslated end of all viral transcripts. TAR acts as a binding site for viral and cellular proteins. In an attempt to identify...

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Bibliographic Details
Main Authors: Lebars, Isabelle, Legrand, Pierre, Aimé, Ahissan, Pinaud, Noël, Fribourg, Sébastien, Di Primo, Carmelo
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602780/
https://ncbi.nlm.nih.gov/pubmed/18996893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn831
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