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NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA-modified aptamer
The trans-activating responsive (TAR) RNA element located in the 5′ untranslated region of the HIV-1 genome is a 57-nt imperfect stem-loop essential for the viral replication. TAR regulates transcription by interacting with both viral and cellular proteins. RNA hairpin aptamers specific for TAR were...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2094059/ https://ncbi.nlm.nih.gov/pubmed/17768146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm655 |
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