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LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1

One of the major limitations of the use of phosphodiester oligonucleotides in cells is their rapid degradation by nucleases. To date, several chemical modifications have been employed to overcome this issue but insufficient efficacy and/or specificity have limited their in vivo usefulness. In this w...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Darfeuille, Fabien, Bo Hansen, Jens, Orum, Henrik, Di Primo, Carmelo, Toulmé, Jean-Jacques
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2004
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC434442/
https://ncbi.nlm.nih.gov/pubmed/15181175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh636
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