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LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1

One of the major limitations of the use of phosphodiester oligonucleotides in cells is their rapid degradation by nucleases. To date, several chemical modifications have been employed to overcome this issue but insufficient efficacy and/or specificity have limited their in vivo usefulness. In this w...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Darfeuille, Fabien, Bo Hansen, Jens, Orum, Henrik, Di Primo, Carmelo, Toulmé, Jean-Jacques
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2004
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC434442/
https://ncbi.nlm.nih.gov/pubmed/15181175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh636
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