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LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1
One of the major limitations of the use of phosphodiester oligonucleotides in cells is their rapid degradation by nucleases. To date, several chemical modifications have been employed to overcome this issue but insufficient efficacy and/or specificity have limited their in vivo usefulness. In this w...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC434442/ https://ncbi.nlm.nih.gov/pubmed/15181175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh636 |
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