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LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1

One of the major limitations of the use of phosphodiester oligonucleotides in cells is their rapid degradation by nucleases. To date, several chemical modifications have been employed to overcome this issue but insufficient efficacy and/or specificity have limited their in vivo usefulness. In this w...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Darfeuille, Fabien, Bo Hansen, Jens, Orum, Henrik, Di Primo, Carmelo, Toulmé, Jean-Jacques
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC434442/
https://ncbi.nlm.nih.gov/pubmed/15181175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh636
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