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LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1
One of the major limitations of the use of phosphodiester oligonucleotides in cells is their rapid degradation by nucleases. To date, several chemical modifications have been employed to overcome this issue but insufficient efficacy and/or specificity have limited their in vivo usefulness. In this w...
में बचाया:
| मुख्य लेखकों: | , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2004
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC434442/ https://ncbi.nlm.nih.gov/pubmed/15181175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh636 |
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