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Loop–loop interaction of HIV-1 TAR RNA with N3′ → P5′ deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription
A hairpin RNA aptamer has been identified by in vitro selection against the transactivation-responsive element (TAR) of HIV-1. A nuclease-resistant N3′ → P5′ phosphoramidate isosequential analog of this aptamer also folds as a hairpin and forms with TAR a loop–loop “kissing” complex with a binding c...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
The National Academy of Sciences
2002
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124987/ https://ncbi.nlm.nih.gov/pubmed/12105271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122247199 |
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