Loop–loop interaction of HIV-1 TAR RNA with N3′ → P5′ deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription

A hairpin RNA aptamer has been identified by in vitro selection against the transactivation-responsive element (TAR) of HIV-1. A nuclease-resistant N3′ → P5′ phosphoramidate isosequential analog of this aptamer also folds as a hairpin and forms with TAR a loop–loop “kissing” complex with a binding c...

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Bibliographic Details
Main Authors: Darfeuille, Fabien, Arzumanov, Andrey, Gryaznov, Sergei, Gait, Michael J., Di Primo, Carmelo, Toulmé, Jean-Jacques
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC124987/
https://ncbi.nlm.nih.gov/pubmed/12105271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122247199
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