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Transition State Structure for the Hydrolysis of NAD(+) Catalyzed by Diphtheria Toxin
Diphtheria toxin (DTA) uses NAD(+) as an ADP-ribose donor to catalyze the ADP-ribosylation of eukaryotic elongation factor 2. This inhibits protein biosynthesis and ultimately leads to cell death. In the absence of its physiological acceptor, DTA catalyzes the slow hydrolysis of NAD(+) to ADP-ribose...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1997
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2601651/ https://ncbi.nlm.nih.gov/pubmed/19079637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja971317a |
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